Chiang A, Lin C, Chuang C, Chang H, Hsieh C, Yeh C, Shih C, Wu J, Wang G, Chen Y, Wu C, Chen G, Ching Y, Lee P, Lin C, Lin H, Wu C, Hsu H, Huang Y, Chen J, Chiang H, Lu C, Ni R, Yeh C, Hwang J (2011). “Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution.” Curr Biol, 21(1), 1-11. doi: 10.1016/j.cub.2010.11.056.

@Article{chiang2011,
  abstract = {Animal behavior is governed by the activity of interconnected brain circuits. Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors.},
  author = {Ann-Shyn Chiang and Chih-Yung Lin and Chao-Chun Chuang and Hsiu-Ming Chang and Chang-Huain Hsieh and Chang-Wei Yeh and Chi-Tin Shih and Jian-Jheng Wu and Guo-Tzau Wang and Yung-Chang Chen and Cheng-Chi Wu and Guan-Yu Chen and Yu-Tai Ching and Ping-Chang Lee and Chih-Yang Lin and Hui-Hao Lin and Chia-Chou Wu and Hao-Wei Hsu and Yun-Ann Huang and Jing-Yi Chen and Hsin-Jung Chiang and Chun-Fang Lu and Ru-Fen Ni and Chao-Yuan Yeh and Jenn-Kang Hwang},
  doi = {10.1016/j.cub.2010.11.056},
  journal = {Curr Biol},
  month = {Jan},
  number = {1},
  pages = {1-11},
  pmid = {21129968},
  title = {Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution},
  volume = {21},
  year = {2011},
}

Costa M, Manton JD, Ostrovsky AD, Prohaska S, Jefferis GSXE (2016). “NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases.” Neuron, 91(2), 293-311. doi: 10.1016/j.neuron.2016.06.012.

@Article{Costa:2016aa,
  abstract = {Neural circuit mapping is generating datasets of tens of thousands of labeled neurons. New computational tools are needed to search and organize these data. We present NBLAST, a sensitive and rapid algorithm, for measuring pairwise neuronal similarity. NBLAST considers both position and local geometry, decomposing neurons into short segments; matched segments are scored using a probabilistic scoring matrix defined by statistics of matches and non-matches. We validated NBLAST on a published dataset of 16,129 single Drosophila neurons. NBLAST can distinguish neuronal types down to the finest level (single identified neurons) without a priori information. Cluster analysis of extensively studied neuronal classes identified new types and unreported topographical features. Fully automated clustering organized the validation dataset into 1,052 clusters, many of which map onto previously described neuronal types. NBLAST supports additional query types, including searching neurons against transgene expression patterns. Finally, we show that NBLAST is effective with data from other invertebrates and zebrafish. VIDEO ABSTRACT.},
  author = {Marta Costa and James D Manton and Aaron D Ostrovsky and Steffen Prohaska and Gregory S X E Jefferis},
  doi = {10.1016/j.neuron.2016.06.012},
  journal = {Neuron},
  month = {Jul},
  number = {2},
  pages = {293-311},
  pmc = {PMC4961245},
  pmid = {27373836},
  title = {NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases},
  volume = {91},
  year = {2016},
}

Lee P, Chuang C, Chiang A, Ching Y (2012). “High-throughput Computer Method for 3D Neuronal Structure Reconstruction from the Image Stack of the Drosophila Brain and Its Applications.” PLoS Comput Biol, 8(9), e1002658.

@Article{lee2012,
  author = {Ping-Chang Lee and Chao-Chun Chuang and Ann-Shyn Chiang and Yu-Tai Ching},
  journal = {PLoS Comput Biol},
  month = {Sep},
  number = {9},
  pages = {e1002658},
  title = {High-throughput Computer Method for 3D Neuronal Structure Reconstruction from the Image Stack of the Drosophila Brain and Its Applications},
  volume = {8},
  year = {2012},
}
  • Alexander Bates. Contributor. ORCID

  • Gregory Jefferis. Author, maintainer. ORCID

  • James Manton. Author. ORCID